On retrouve dans cette série, entre autres :
Chad Michael Murray (Lucas Scott),
Brett Claywell (Tim Smith),
Bryan Greenberg (Jake Jaglieski),
Sophia Bush (Brooke Davis Baker),
Hilarie Burton (Peyton Sawyer Scott),
Bethany Joy Lenz (Haley James Scott),
James Lafferty (Nathan Scott),
Maria Menounos (Julia / Emily Chambers),
Michael Copon (Felix Taggaro),
Daniella Alonso (Anna Taggaro),
Rey Valentin (Nicolas "Nick" Chavez),
Kieren Hutchison (Andy Hargrove),
Cullen Moss (Jonathan "Junk" Moretti),
Thomas Ian Griffith (Larry Sawyer),
Kevin Federline (Jason),
Lindsey McKeon (Taylor James),
Sheryl Lee (Elizabeth ),
Michael Trucco (Cooper Lee),
Katherine Bailess (Erika Marsh),
Elisabeth Harnois (Shelly Simon),
Kelsey Chow (Gigi Silveri),
Matt Barr (Ian Banks),
Ernest Waddell (Derek Sommers ),
Rick Fox (Daunte Jones),
Amber Wallace (Glenda Farrell),
Barry Corbin (Brian "Whitey" Durham),
Shantel VanSanten (Quinn James),
Austin Nichols (Julian Baker),
Robert Buckley (Clay Evans),
Paul Johansson (Dan Scott),
Moira Kelly (Karen Roe),
Kate Voegele (Mia Catalano),
Craig Sheffer (Keith Scott),
Barbara Alyn Woods (Deborah ),
Lee Norris (Marvin "Micro" McFadden),
Antwon Tanner (Antwon ),
Danneel Ackles (Rachel Gatina),
Jackson Brundage (James ),
Lisa Goldstein (Millicent Huxtable),
Jana Kramer (Alex Dupré),
Tyler Hilton (Chris Keller),
Stephen Colletti (Chase Adams),
Emmanuelle Vaugier (Nikki),
Bevin Prince (Bevin Mirskey),
Vaughn Wilson (Ferguson ), et
Robbie Jones (Quentin Fields).
Est présent dans la série "
Pretty Little Liars" (Melissa Hastings)
Est présent dans la série "
The Vampire Diaries" (Meredith)